zuCarb Rare Sugars for Research and Development
The Midwest Bioprocessing Center provides a growing number of rare and modified monosaccharides, sugar phosphates and activated nucleoside sugars for R&D Applications. Our unique zuCarb™ chemoenzymatic production technology allows us to make many of these important research glycochemicals in quantities not available previously.
For more information, download the product catalog and contact us to purchase.
We synthesize custom glycochemical products.
If you don’t see what you’re looking for in our catalog contact us to see how we can help you with custom synthesis of L-sugars, sugar-phosphates, activated sugars and other custom synthesis or glycodiversification projects! The zuCarb™ technology platform also allows us to take on a wide variety of custom oligosaccharide synthesis projects. Applications include:
- Therapeutic and Research Oligosaccharides
- Human Milk Oligosaccharides
- Anti-infective and Anti-cancer applications
- Many Others
Let us know what you are looking for!
Application Focus: Viral Glycobiology Research
Glycobiology is important in a number of ways for viral research. Viral surface proteins are often heavily glycosylated to both avoid recognition by the host cell and, in some cases, interact with host receptors. For example, the spike protein glycosylation of the SARS-CoV-2 virus is usually the extension of an N-linked core pentasaccharide compound, composed of a stem of chitobiose followed by mannoses to form two antennary complexes. Understanding glycosylation of viral spike proteins and their potential epitope masking is of fundamental importance for vaccine research.
Viral receptors which are recognized by many viruses are also glycosylated proteins as well. SARS-CoV-2 and others uses angiotensin-converting enzyme 2, (ACE2) as its receptor, and other ß-coronaviruses, utilize sialic acid residues on cellular glycoproteins as receptors.
Glycans are currently being studied as vaccines against viruses (Dengue, Hepatitis C), parasites (Plasmodium) and fungi (Candida). Human milk oligosaccharides (HMOs) have been shown to reduce the possibility of infections due to interference with adhesion of pathogenic bacteria and potentially viruses. Galectins have been shown have pro- or anti-viral properties and play important role in innate immunity. Finally, some galectin inhibitors may block HIV infection of T cells.
Oligosaccharides are currently isolated from nature or synthesized at extremely low yield via a complex set of protection and deprotection steps. At the Midwest Bioprocessing Center we are developing new enzymatic technology to build the key activated sugar building blocks needed to make key glycans and custom oligosaccharides needed to support and spawn additional research in this important field.